CD4 and Granuloma: Compared to BCG-induced granulomas, where the ratio of CD4+:CD8+ T cells was 3:1, their number was significantly (p ≤ 0.05) increased in VPM1002-, PDX- and NUOG-induced granulomas, resulting in CD4+:CD8+ T cell ratios of 1.4:1, 1:1 and 0.6:1, respectively.