The essential components of human histone pre-mRNA 3′-end processing have also recently been defined by the reconstitution and structural studies, which include the histone pre-mRNA cleavage complex (HCC), the stem loop binding protein (SLBP), the U7 small nuclear ribonucleoprotein (snRNP), and FLASH [30]. This evidence concerns the gene SLBP and hepatocellular carcinoma.