REN and cardiac hypertrophy: One study assessed multiple signaling pathways associated with the MedDiets from the PREDIMED cohort and found MedDiets with either nuts or extra-virgin olive oil reduced hypoxia signaling in the cardiovascular system (CVS), eNOS signaling, nitric oxide signaling in the CVS, renin-angiotensin signaling, aldosterone signaling in epithelial cells, P2 gamma purigenic receptor signaling pathway, and cardiac hypertrophy signaling [56].