The univariate analysis using SPSS showed that the HLA-B*08 allele (p = 0.022) was associated to the low PDA group with a significant p ≤ 0.05 and the HLA-B*52 allele (p = 0.018) was associated to the medium and high PDA group with a significant p ≤ 0.05 (Table 2). The gene discussed is HLA-B; the disease is Patent ductus arteriosus.