Mutations in the Leucine-Rich Repeat Kinase 2 (LRRK 2), Parkin RBR E3 ubiquitin-protein ligase (PARK 2 and 7), PTEN-induced putative kinase (PINK1), and SNCA genes are known to cause familial PD, and some complex interaction in the gene variants could also lead to PD sporadically [14]. This evidence concerns the gene SNCA and Parkinson disease.