In distinction, amyloid-β (Aβ) aggregation and neurofibrillary tangles are linked to hyperphosphorylated tau in AD, mutated huntingtin (HTT) in HD, and TAR DNA-binding protein 43 (TDP-43) in ALS [44,45,46,47]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.