The expression of SHANK2 was reduced in advanced-stage tumours in the KIRC and KIRP datasets (p < 0.001 and p = 0.025, respectively; Figure 3A), and low SHANK2 expression levels were significantly associated with a poor survival of patients (p < 0.001 and p = 0.041, respectively; Figure 3B). The gene discussed is SHANK2; the disease is neoplasm.