MSH2 and colorectal cancer: They include ones with endometrial or colorectal cancer with evidence of microsatellite instability or loss of dMMR protein (MLH1, MSH2, MSH6, PMS2); first-degree relative affected with endometrial or colorectal cancer either diagnosed before 60 years or at risk for LS; first- or second-degree relative with a known MMR gene mutation [21].