FGFR1 and lung cancer: In lung cancer, Schildhaus et al. proposed that high-level amplification is defined as FGFR1/centromere 8 (CEN8) ratio ≥ 2.0, or average number of FGFR1 signals per tumor cell nucleus ≥ 6 or the percentage of tumor cells containing ≥ 15 FGFR1 signals or large clusters ≥ 10% [133].