Consequently, these pathways were identified early on as potential targets for cancer therapy by either inhibiting downstream signaling (e.g., alpelisib or copanlisib targeting phosphoinositide-3-kinase (PI3K), temsirolimus and other rapalogs targeting mammalian/mechanistic target of rapamycin (mTOR) or trametinib targeting mitogen-activated protein kinase kinase (MAPK/MEK)) or by directly interfering with upstream receptors. The gene discussed is WNK2; the disease is cancer.