Recently, a tenascin-C-derived peptide (TNIIIA2) that activates integrin β1 was tested with retinoic acids, i.e., ATRA [168] or acyclic retinoid [169], and was shown to decrease the survival of IMR-32 cells, reduce protein levels of MYCN (by its proteasomal degradation) and aurora A, and impair tumor growth in mice. Here, MYCN is linked to neoplasm.