Other frequently mutated genes in NB include telomerase reverse transcriptase (TERT), SH3 and multiple ankyrin repeat domains 2 (SHANK2), protein tyrosine phosphatase receptor type D (PTPRD), ALK receptor tyrosine kinase (ALK), and ATRX chromatin remodeler (ATRX) [17]. The gene discussed is SHANK2; the disease is neuroblastoma.