In contrast to an often-aggressive course of HR NB, e.g., children with NB without MYCN amplification and 11q aberration grouped in “metastatic special” (i.e., the MS stage of INGRSS—with NB disseminated to skin, liver, and/or restricted bone marrow involvement and age <18 months) have very good prognoses [9]. This evidence concerns the gene MYCN and neuroblastoma.