GPC3 and hepatocellular carcinoma: Notably, a loss-of-function mutation of the gene encoding glypican-3 (GPC3) is linked to Simpson–Golabi–Behmel syndrome, an overgrowth syndrome linked to the X chromosome, accompanied by an increased incidence of embryonal tumors such as hepatoblastoma, NB, gonadoblastoma, Wilms tumor, and hepatocellular carcinoma [59].