Interestingly, Kekäläinen et al. found that sterility in Aire−/− mouse males could be reversed in the absence of T and B cells, i.e., Aire−/−Rag1−/− mice were found to be fully fertile which led the authors to suggest an autoimmune aetiology of infertility in Aire−/− males [29]. This evidence concerns the gene AIRE and Infertility.