F1: decreased FSH (500 mg/kg), estradiol (20 μg/kg; 200 and 500 mg/kg) testosterone (200 μg/kg; 200 and 500 mg/kg levels) and progesterone (500 mg/kg) levels; decreased steroidogenesis (20 and 200 μg/kg; 500 mg/kg); altered transition among follicle types (20 μg/kg and 200 mg/kg); higher incidence of atresia (500 mg/kg) F2 and F3: increased number of cystic ovaries (all doses); breeding, pregnancy and delivery complications (20 μg/kg and 500 mg/kg). The gene discussed is BRD2; the disease is Ovarian cyst.