HDAC8-mediated deacetylation of H3/H4 histones at promoter or enhancer regions is involved in transcriptional repression of several genes such as interferon beta 1 (IFNB1), suppressor of cytokine signaling 1/3 (SOCS1/3), sirtuin 7 (SIRT7), mitogen-activated protein kinase kinase 3 (MAP2K3), C-C motif chemokine 4 (CCL4), inhibitor of DNA binding 2 (ID2), BCL2 interacting protein 3 (BNIP3), and metastatic lymph node 64 (MLN64) [54,55,56,57,58,59,60] (Table 1). The gene discussed is MAP2K3; the disease is benign neoplasm.