SLC2A4 and Insulin resistance: Interestingly, it has also been shown that the overexpression of TFEB reverses the suppressed glucose uptake of palmitate-induced insulin resistance in C2C12 myotubes via the restoration of the insulin-dependent GLUT4 signaling pathway and the activation of AMPK, a key energy sensor, which regulates glucose metabolism and has been shown to protect against insulin resistance.