TFEB and neoplasm: Consistent with these findings, the treatment of tumor-associated macrophages (TAMs) with chloroquine, an antimalarial drug, promotes lysosomal calcium release that contributes to TFEB activation and increases the presence of genes involved in glycolysis, such as GLUT1 and GLUT4, phosphofructokinase (PFKM), and pyruvate kinase (PKLR); these effects are TFEB-dependent since the regulation was blocked after TFEB knockdown.