Once activated, TFEB directly binds to the promoter sequences to augment the expression of autophagy–lysosome-related genes, and its dysregulation of TFEB activity might contribute to the development of several diseases, including hepatic steatosis, neurodegenerative diseases, cancer, and inflammatory diseases [14,15,16,17,18,19,20]. The gene discussed is TFEB; the disease is fatty liver disease.