In nonalcoholic fatty liver disease (NAFLD) patients, hepatic steatosis alters the subcellular location of TFEB, being mainly cytosolic; as TFEB promotes genes related to lipid metabolism, TFEB activation could be an important factor in determining the severity of hepatic steatosis in NAFLD patients and might conceivably be related to reduced lipophagy activity [123]. This evidence concerns the gene TFEB and metabolic dysfunction-associated steatotic liver disease.