Several reports have demonstrated that the expression of the chemokine XCL1 by NK cells plays an important role in the tumor microenvironment (TME) recruitment of XCR1+ type 1 DCs (cDC1), which is a cell subtype crucial for the orchestration of an effective CD8+ T cell-mediated tumor immune response, due to the excellence of its performance at antigen cross-presentation [6,7]. This evidence concerns the gene CD8A and neoplasm.