In pre-treatment tumor biopsies derived from NSCLC patients, the increased expression in the TME of the NK cell-specific transcriptional signature, developed by Ascierto ML et al. [30], together with other genes associated with NK cell priming of the adaptive immune response, correlated with a better response to anti-PD(L)1 immunotherapy. This evidence concerns the gene CD274 and non-small cell lung carcinoma.