While circulating NKp46+ NK cells have been associated with better prognosis in colorectal cancer (CRC) [19], Picard et al. [20] reported the association of NKp46+ NK cells with poor patient survival in Non-Small Cell Lung Cancer (NSCLC) patients, suggesting the ability of these cells to suppress anti-tumor Th1 immunity. This evidence concerns the gene NCR1 and colorectal carcinoma.