WNT5A and HIV infectious disease: The injection of the viral protein HIV1-gp120, a model of neuropathic pain associated with HIV infection, induces Wnt3a upregulation in microglia [47,48], Wnt5a, and pro-inflammatory molecules IL-1β, IL-6, and TNF-α at the spinal cord level; intrathecal injection of Wnt5a antagonist Box5 significantly reduces the levels of inflammatory cytokines [46].