In cancer conditions and different models of chronic pain, such as tumor-cell-induced pain (TCI), chemotherapy-induced neuropathic pain (PTX-induced pain), and chronic constriction injury (CCI, a model of neuropathic pain with a strong inflammatory component), Wnt ligands such as Wnt3a, Wnt5b, and Wnt10a; Wnt receptors such as Fzd8 and Ryk; and signaling molecules such as β-catenin, GSK-3β, and TCF4 are upregulated in DRGs [29,36]. The gene discussed is WNT3A; the disease is cancer.