EPHB1 and cancer: Furthermore, blocking Eph–ephrin signaling in different contexts of chronic, inflammatory, neuropathic, and cancer-associated pain by injection of EphB1-Fc attenuates, not only thermal hypersensitivity and mechanical allodynia, but also the activation of p38, JNK, and ERK [167,175], the PI3K-Akt pathway [168], and PKCγ and PKA [172,174].