FRMD6 and Alzheimer disease: As oxidative stress and mitochondrial dysfunction are key early pathological features of AD [37,42,52,53,54,55], and are thus promising targets for the modulation/prevention of downstream neurodegeneration, in the present study, we addressed the key unexplored question of whether Willin/FRMD6 is involved in mitochondrial dysfunction in neurons and neuronal cell lines insulted by Aβ and oxidative stress.