STAT3 and cancer: For instance, N-4-hydroxyphenylretinamide (4-HPR) was highly bound at STAT3’s dimerization site and c-Abl and c-Src ATP-binding kinase sites to suppress cancer-promoting pathways including STAT3 phosphorylation, STAT3-DNA binding, and production of the trans-signaling enabling sIL-6R [138].