In this study, we fully investigated the FGFR2 mutation p.Cys342Arg detected in two Chinese Crouzon syndrome patients and revealed the novel mechanism whereby FGFR2 p.Cys342Arg -AMPK-Erk1/2 axis regulates osteogenesis by enhancing the mitochondrial metabolism (Figure 8C). Here, MAPK3 is linked to Crouzon disease.