ORAI1 and cancer: In agreement with previous reports on other cancer cell types [40,52], serum-evoked SOCE (Figure 6A) was dampened by blocking Orai1 channels with either Pyr6 (10 μM) (Figure 6B,D) or BTP-2 (20 μM) (Figure 6C,D) in MDA-MB-231 cells.