Recently, novel SCN1A-related phenotypes have been described, including severe DEEs of non-Dravet syndromes: neonatal developmental and epileptic encephalopathy with a movement disorder and arthrogryposis (NDEEMA), developmental and epileptic encephalopathy with a movement disorder (EIDEE/MD), epileptic encephalopathy (EIDEE) [15]. This evidence concerns the gene SCN1A and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.