As this is not only a scientific dilemma but also an everyday diagnostic problem, in silico prediction tools, such as the SCN1A-Epilepsy Prediction Model (https://scn1a-prediction-model.broadinstitute.org/; (accessed on 20 September 2022), funNCion (https://funnc.shinyapps.io/shinyappweb/; (accessed on 20 September 2022) and PER viewer (https://per.broadinstitute.org/; (accessed on 20 September 22022), are being developed to solve it. This evidence concerns the gene SCN1A and epilepsy.