Interestingly, one study did identify the Nr4a nuclear receptor family member Nr4a1 in suppressing Runx3 expression and restraining CD8+ T cell development [79], but it was later demonstrated that loss of Nr4a function had no significant effects on Runx3 expression levels in CD8+ TILs (Tumor-infiltrating lymphocytes) [75]. The gene discussed is RUNX3; the disease is neoplasm.