In order to determine if PELI1 could regulate signals in the COPD process, we first screened a series of genes associated with COPD and found a positive correlation between Pellino-1 and p21 expression in the GTEx-lung database and TCGA para-carcinoma lung tissue database using GEPIA online tools (Figure 1A and Figure S1). Here, PELI1 is linked to chronic obstructive pulmonary disease.