ADAM17 and MAML3 are indexed in the KEGG “Notch signaling pathway”, and BMP2 and SMAD5 are indexed in the KEGG “TGF-beta signaling pathway” (Tables S2 and S3), which confirms our data on the involvement of these processes in the formation of glioma neurospheres. The gene discussed is ADAM17; the disease is central nervous system cancer.