Because heterozygous expression of an NS/NSML (LEOPARD syndrome) mutant of SHP2 enhances energy metabolism and protects against obesity and diabetes [69], one might wonder if equivalent pharmacological modulation of SHP2, that functionally mimics NSML mutations, could be a powerful strategy to alleviate obesity and associated pathologies. Here, PTPN11 is linked to obesity due to melanocortin 4 receptor deficiency.