BRCA1 and ovarian cancer: It positively regulates mRNA levels of many HRR genes, including BRCA1 and BRCA2, which are frequently mutated in familial breast and ovarian cancers [41,52,53], BLM helices [54], CtIP [55,56] and all members of the MRN complex (MRE11, Nbs1 and RAD50) [40,57] (see Table 1 for additional DSB repair genes that are regulated by estrogen).