In line with these findings, the negative regulation of Tip60 by PXR was visualized in a PTX-resistant NSCLC model, and the interaction existed in all phases of the cell cycle, especially the S-phase, suggesting that PXR-regulated Tip60 protein post-translational modifications contribute to the development of PTX resistance, and might be the potential target to overcome PTX-resistance. The gene discussed is KAT5; the disease is non-small cell lung carcinoma.