The importance of cytoskeletal architecture also passes by the maintenance of proper actomyosin complexes, which are especially important in ALS due to their function in the motor system; it has been shown that primary myotubes from transgenic ALS mice have different mechanical characteristics compared to WT with an increase in elastic modulus values that appear to occur early in the disease pathogenesis, with an increase in Actin and a decrease in Myosin gene expression (Figure 5c) [194]. This evidence concerns the gene MYH14 and amyotrophic lateral sclerosis.