KANK1 and amyotrophic lateral sclerosis: The involvement of the cytoskeleton in the development of ALS has been supported by GWAS identification of mutations on cytoskeleton-related proteins such as Kinesin 5A (KIF5A), required for axonal transport, and the Actin polymerization regulating protein KN motif and ankyrin repeat domain-containing protein 1 (KANK1), which were shown to correlate with disease severity (Figure 5c) [185,186].