Recent studies highlighted that expression of Hippo pathways components is downregulated in post-mortem human AD brains [219], and YAP downregulation is thought to occur at the early stages of AD, contributing to amyloid plaques formation and Tau hyperphosphorylation, suggesting an upstream regulator role in the AD molecular pathogenic pathways (Figure 3c) [217]. Here, MAPT is linked to Alzheimer disease.