Altogether, the present data contribute important additional pieces of knowledge in the understanding the complexity of the mechanisms related to CGRP in migraine pathogenesis; it seems reasonable to hypothesize that the miRNAs and cytokines investigated, together with the increased TRPA1 gene expression, may represent only a part of a multi-biomarker panel signature of the migraine disease. The gene discussed is TRPA1; the disease is migraine disorder.