PRKD1 and cholangiocarcinoma: To interrogate whether inhibition of the kinase activity of the PKD family would suppress the cell proliferation and migration of CCA cells, 1-naphthyl PP1 (1-NA-PP1), which is a selective and effective pan-inhibitor of the PKD family [35], was used to treat both TFK-1 and HuCCT1 cells (Figure 8).