Moreover, the molecular pathogenesis of CCA includes aberrant signaling pathways, such as receptor tyrosine kinase (RTK) [10], RAS-mitogen-activated protein kinase (MAPK) [11], and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling [12]. The gene discussed is AKT1; the disease is cholangiocarcinoma.