TNF and atherosclerosis: To determine the effect of the BETi JQ1 on primary human endothelial cells in a cellular model, mimicking aspects of atherosclerosis, HUVECs were exposed to laminar SS (25 dyn/cm2) with or without 25 ng/mL TNFα treatment in the presence or absence of 500 nM JQ1 and compared with a control group without any treatment.