Immunohistochemistry for CD31 and Nogo-B in HCC tissues from 167 patients with HCC showed that 94 (56.3%) patients exhibited low Nogo-B expression and 73 (43.7%) patients displayed high Nogo-B expression in HCC endothelial cells compared with the peri-tumor endothelial cells (Figure 1C). The gene discussed is RTN4; the disease is hepatocellular carcinoma.