CASR and diabetic cardiomyopathy: The CaSR-regulated cytosolic and organellar Ca2+ levels activate various pathways, leading to two different endpoints: the sublethal (possibly reversible) or lethal (cell death) changes responsible for subsequent reactions to injury, such as remodeling (i.e., hypertrophy) and repair (i.e., diabetic cardiomyopathy and fibrosis).