The results of in vitro and in vivo studies in spinal cord neurons showed that the expressions of the CaSR and calpain increased during the spinal cord ischemia–reperfusion injury (SCIRI), and the expressions of calpains were enhanced or decreased by the CaSR agonist GdCl3 and antagonist NPS-2390, respectively [51]. Here, CASR is linked to spinal cord ischemia.