The calcium-sensing receptor (CaSR) is a recognized member of G-protein-coupled receptors (GPCRs) Class III or Family C and plays multiple roles in animal cells, such as cell proliferation, apoptosis, autophagy, migration, and invasion, which contributes to CaSR signaling as a potential therapeutic target for related physiological disorders, diseases, or even cancer intervention [1,2,3]. This evidence concerns the gene CASR and cancer.