FOXP3 and neoplasm: Based on the immune cell populations and the mechanisms for evading the anti-tumor immune response, Karamitopoulou classified PDACs into three immunologic subtypes: the immune-escape subtype, which has high FOXP3+Treg cells and M2-macrophages but low cytotoxic T-cells and M1 macrophages; the immune-rich subtype, which has high TILs and tertiary lymphoid structures but a low infiltration of FOXP3+T regulatory cells and M2 macrophages; and the immune exhausted subtype, which has MSI/dMMR, high TILs, and the overexpression of immune checkpoints [108].