FYN and Huntington disease: Considering that Fyn phosphorylation of GluN2B at Tyr1472 is associated with enrichment of synaptic NMDARs, when compared with extrasynaptic membrane receptors [6], and we recently observed diminished Fyn in several HD models [15], we further analyzed Fyn total and phosphorylated levels at Tyr416, the latter indicating SKF activation since all the family members share the C-terminal.