E2F1 and type 2 diabetes mellitus: Overall, our data suggest that E2F1 up-regulates the expression of miRNA-206 and 210-5p in human VAT, situating the E2F1-miRNA-206/210-5p pathway as an addition to an intricate E2F1-regulated network in visceral adipose tissue, which may contribute to an obesity phenotype complicated by T2DM.