E2F1 and obesity due to melanocortin 4 receptor deficiency: Yet, in cohort 2, in patients with extreme obesity and in whom high-VAT-E2F1 was associated with T2DM, while lipid profile was not associated with miRNA-206 or miRNA-210-5p expression (Table 4), significant correlations were observed between the miRNAs and glycemic parameters (FPG, FPI): miRNA-206 correlated with FPG levels and miR-210-5p correlated with both FPG and fasting plasma insulin (FPI) levels (Table 4, Figure 6A–C, respectively), signifying a systemic glucose-intolerant/insulin-resistant profile.