HTR2A and Anxiety: To note, the conclusion is well-consistent with the existence of presynaptic 5-HT2A receptors on thalamo-cortical synapses that control the thalamo-frontal connectivity and the associated cognitive functions [45], but also with the existence of presynaptic 5-HT2A heteroreceptors controlling the glutamate release from layer V pyramidal neurons and modulating conflict anxiety behaviors [46].