Understanding the events underlying 5-HT2A-mGlu2 metamodulation is particularly relevant since, besides its physiological relevance, this receptor–receptor crosstalk might also be involved in the development of central diseases typified by ongoing glutamate overactivity, including schizophrenia, and suggests new targets for innovative therapeutic interventions for the cure of these disorders. The gene discussed is HTR2A; the disease is schizophrenia.