The unbalance of the 5-HT2A-mGlu2/3 crosstalk was proposed to contribute to the pathogenesis of schizophrenia and drugs recovering the 5-HT2A-mGlu2/3 receptor–receptor interaction to physiological levels, which were predicted to be therapeutics for the cure of this disorder. The gene discussed is HTR2A; the disease is schizophrenia.