Meta-analysis of combined data from SAVOR-TIMI 53, EXAMINE, TECOS, and CARMELINA demonstrated a neutral effect of DPP4 inhibitors on MI [odds ratio (OR): 1.01; p = 0.88; 95% CI: 0.92–1.10], stroke (OR: 0.99; 95% CI: 0.87–1.13; p = 0.88), combined endpoints of MI and stroke (OR: 1.00; 95% CI: 0.93–1.08; p = 0.97), and CV death (OR: 0.99; 95% CI: 0.91–1.09; p = 0.87). This evidence concerns the gene DPP4 and Stroke.