Further investigations of this combination regimen in pMMR/MSS metastatic colon cancer are warranted, especially in patients with high immunoscore IC (a synthetic measure of CD8+ T lymphocyte infiltration, programmed death ligand 1 (PD-L1) cell abundance, and the proximity between PD-L1 cells and CD8+ T-cells) or high tumour mutational burden. This evidence concerns the gene CD8A and neoplasm.