Secretion of inflammatory cytokines: TNF-α, IL-12p70, IL-23, TNF-α, IL-1, IL-6, IL-8, IL-12, IL-18 and chemokines: CCL3, CCL4 and CXCL8.Uptake of exogenous antigens, specifically tumor antigen.T immune responses against extracellular bacterial and fungal pathogens.Polarization of Th17, Th2, Th1, Th22, Treg and cytotoxic responses.By the induction of Th2 responses are involved in humoral responses via IL-6 and IL-1β secretion.Higher potential to induce CD4+ T cell proliferation than cDC1.CD5high cells induce IL-10 producing Treg cells, whereas CD5low cells induce IFNγ producing T cells. This evidence concerns the gene TNF and neoplasm.