Relatively homogenous population in comparison to cDC2.Polarize activated CD4+ T cells toward Th1 and away from Th2 phenotype.Major source of IL-12 in vivo.Immune responses against cancer and pathogens infection.CLEC9+ CD141+ cells are producers of IFNγ and CD8+ T cell activation by cross presentation in response to TLR-3 ligation. The gene discussed is TLR3; the disease is cancer.