For example, data considering three different tumor types reveled gene upregulation associated with ROS and NOTCH signaling and keratan sulfate metabolism in tumor infiltrating cDC1s; hypoxia and Wnt/β catenin pathway and methionine metabolism were found in cDC2s; TNFα/NFκB and IFN signaling, together with folate and tryptophan metabolism in migratory cDC2s; and Kras signaling and sphingolipid, lysine, purine and arginine metabolism in pDCs [201]. This evidence concerns the gene TNF and neoplasm.