We have reported the co-enrichment and co-localization of the two hallmark proteins, SYN and TPPP1, as visualized in neurons and oligodendrocytes (OLGs) in the brain samples of patients with PD and MSA, respectively, in spite of the fact that in the normal brain SYN and TPPP/p25 are expressed in distinct cell types ([5] and references therein). Here, TPPP is linked to Parkinson disease.