CNR1 and brain ischemia: We have reported that CB1 receptor antagonists are neuroprotective in organotypic hippocampal slices exposed to OGD, whereas CB1 agonists exacerbate OGD injury [44] in a similar, but not additive manner to what observed with DHPG, suggesting that CB1 receptor activation may also contribute to the neurodegenerative mechanisms following cerebral ischemia.