To evaluate the effect of hypoxia induced AnxA6 on the response of TNBC cells to lapatinib treatment, we treated the AnxA6-low HCC-70 and MDA-468, as well as the AnxA6-high BT-549 and MDA-231 TNBC cell lines (Figure S2) with various concentrations of lapatinib under hypoxia or normoxia for 72 h. Here, ANXA6 is linked to hepatocellular carcinoma.