TNF and obesity due to melanocortin 4 receptor deficiency: During obesity, neutrophils have high neutrophil elastase, neutrophil alkaline phosphatase, myeloperoxidase, IL-6, IL-1β, IL-12, IL-8, and TNF-α, and low expression of IL-10, which favors activation of M1 macrophages and development of chronic inflammation [206,207,208,209,210].