Moreover, Taeye et al. revealed that macrophages are the main sources of TNF-α in the obese WAT [139], transplanted TNF-α deficient mice with TNF-α-sufficient or TNF-α-deficient bone marrow and found that macrophage-derived TNF-α contributes to inflammation development and insulin resistance in diet-induced obesity [139]. This evidence concerns the gene TNF and Insulin resistance.