These previous efforts identified NAP as a peptide agent that enhances microtubule dynamics and Tau-microtubule interactions [11], protects against Tau hyper-phosphorylation [12] and tauopathy [8], and regulates actin–cytoskeletal association [2], leading to dendritic spine formation [8,10,13] that is translated to behavioral protection [13]. Here, MAPT is linked to tauopathy.