As the autophagy-defective melanocytes displayed features resembling premature senescence, accompanied by aberrant Nrf2 signaling, redox unbalance and increased lipid oxidation, Zhang et al., hypothesized a model shared by both autophagy-deficient cells and vitiligo cells, thus pointing to autophagy as a potential factor acting on vitiligo pathogenesis [43]. Here, NFE2L2 is linked to vitiligo.