MAPT and Alzheimer disease: Immunohistochemistry data show that aggregated and hyperphosphorylated tau inclusions are present in glial cells in AD, FTLD-17, and other tauopathies [23,24], and in mice models as well [25,26,27], but how the intracellular trafficking in glial cells would impact propagation of different prion-like strains of tau aggregates is not known and different glia may have protective or enhancing effects [28,29,30].