As a four-transmembrane protein anchored to the endoplasmic reticulum, a previous study found TMEM43 mutation causes arrhythmogenic right ventricular dysplasia/cardiomyopathy and TMEM43 was also reported to be associated with pro-fibrotic cardiomyopathy [15,16]. Here, TMEM43 is linked to Arrhythmogenic right ventricular dysplasia.