ATM and malignant colon neoplasm: Its ectopic overexpression in HCT116 colon cancer cells promotes autophagy by upregulating ATM (ataxia telangiectasia mutated) gene expression, a Ser/Thr protein kinase, and a member of the PI3K (phosphoinositide 3-kinase)-related protein kinase (PIKK) family, and by inhibiting mTORC1 (mechanistic target of rapamycin complex 1) activity [67].