ATG5 and central nervous system cancer: Additionally, in U-251 glioma cells, EMAPII (low-dose endothelial-monocyte-activating polypeptide-II) also downregulates miR-20a and induces autophagy by subsequently increasing the expression of ATG5 (autophagy-related 5) and ATG7, both of which are miR-20a targets [60].