AKT1 and Niemann-Pick disease: Because the AKT/mTOR pathway can be upregulated, at least indirectly, by different members of the miR-17-92 cluster, such as miR17-5p, miR-20a, and miR18a (see previous mentions of this), it is logical to suppose that there is a strong relationship between this miRNA cluster and the metabolic consequences of Niemann–Picks disease.