In addition, it has been recently demonstrated that miR-17-5p targets Mfn2 (Mitofusin 2), a mitochondrial fusion protein that plays a role in balancing autophagy and inhibits its expression, activating the PI3K/AKT/mTOR pathway and suppressing autophagy to promote cardiac hypertrophy [55]. This evidence concerns the gene MFN2 and cardiac hypertrophy.