Moreover, miR-17-5p is also able to suppress autophagy in an osteoarthritis (OA) mice model, in which decreased miR-17-5p expression induces autophagy mainly through suppressing the expression of another of its targets, SQSTM1/p62 (sequestosome 1), thereby contributing to osteoarthritis progression [53]. The gene discussed is SQSTM1; the disease is osteoarthritis.