Thorase cKO mice exhibited substantial α-synuclein (α-syn) accumulation that was co-labeled with high levels of phosphorylated (Ser129) α-syn (pS129-α-syn), the most frequently modified form of α-syn within PD pathological inclusions, and pathogenic fibrillary aggregates (Figure 2A). The gene discussed is ATAD1; the disease is Parkinson disease.