HK2 and cancer: In this regard, some regulatory enzymes, including GLUTs, Hexokinase II (HKII), 6-Phosphofructo-2-kinase (PFKFB3), pyruvate dehydrogenase (PDH), lactate dehydrogenase A (LDHA) and pyruvate kinase M2 (PKM2), should be upregulated to accelerate the rate of glycolysis in cancer cells [45].