PDK1 and breast carcinoma: For instance, Kim et al. understood that miR-155 is overexpressed by breast cancer cells for upregulating c-MYC and activating the phosphoinositide-3-kinase regulatory subunit alpha (PIK3R1)-PDK1/AKT-FOXO3a pathway to boost HK2 expression, thereby accelerating glycolysis and promoting breast cancer progression.