Interestingly, FASN expression was suppressed in BC cells transfected with si-circARL8B and in cells treated with miR-653-5p, while this suppressive effect was abolished when such cells were exposed to pcDNA-HMGA2, indicating that circARL8B exerts its FASN regulatory role by controlling miR-653-5p and HMGA2 expression levels (Figure 2). This evidence concerns the gene HMGA2 and breast cancer.